From Wikipedia, the free encyclopedia
Jump to: navigation, search
Histone cluster 1, H1e
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H1E ; H1.4; H1E; H1F4; H1s-4; dJ221C16.5
External IDs OMIM142220 MGI1931527 HomoloGene130534 GeneCards: HIST1H1E Gene
RNA expression pattern
PBB GE HIST1H1E 208553 at tn.png
PBB GE HIST1H1E 222067 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3008 50709
Ensembl ENSG00000168298 ENSMUSG00000051627
UniProt P10412 P43274
RefSeq (mRNA) NM_005321 NM_015787
RefSeq (protein) NP_005312 NP_056602
Location (UCSC) Chr 6:
26.16 – 26.16 Mb
Chr 13:
23.62 – 23.62 Mb
PubMed search [1] [2]

Histone H1.4 is a protein that in humans is encoded by the HIST1H1E gene.[1][2][3]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]


  1. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H1E histone cluster 1, H1e". 

Further reading[edit]