HIST1H1T

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Histone cluster 1, H1t
Identifiers
Symbols HIST1H1T ; H1FT; H1t; dJ221C16.2
External IDs OMIM142712 MGI1888530 HomoloGene3889 GeneCards: HIST1H1T Gene
RNA expression pattern
PBB GE HIST1H1T 207982 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3010 107970
Ensembl ENSG00000187475 ENSMUSG00000036211
UniProt P22492 Q07133
RefSeq (mRNA) NM_005323 NM_010377
RefSeq (protein) NP_005314 NP_034507
Location (UCSC) Chr 6:
26.11 – 26.11 Mb
Chr 13:
23.7 – 23.7 Mb
PubMed search [1] [2]

Histone H1t is a protein that in humans is encoded by the HIST1H1T gene.[1][2][3]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]

References[edit]

  1. ^ Koppel DA, Wolfe SA, Fogelfeld LA, Merchant PS, Prouty L, Grimes SR (Jun 1994). "Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6". J Cell Biochem 54 (2): 219–30. doi:10.1002/jcb.240540210. PMID 8175896. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H1T histone cluster 1, H1t". 

Further reading[edit]