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Histone cluster 1, H2aa
Protein HIST1H2AA PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H2AA ; H2AA; H2AFR; bA317E16.2
External IDs OMIM613499 HomoloGene108269 GeneCards: HIST1H2AA Gene
RNA expression pattern
PBB GE HIST1H2AA gnf1h05799 at tn.png
More reference expression data
Species Human Mouse
Entrez 221613 319169
Ensembl ENSG00000164508 ENSMUSG00000063021
UniProt Q96QV6 Q8CGP7
RefSeq (mRNA) NM_170745 NM_178183
RefSeq (protein) NP_734466 NP_835490
Location (UCSC) Chr 6:
25.73 – 25.73 Mb
Chr 13:
21.75 – 21.75 Mb
PubMed search [1] [2]

Histone H2A type 1-A is a protein that in humans is encoded by the HIST1H2AA gene.[1][2]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.[2]


  1. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  2. ^ a b "Entrez Gene: HIST1H2AA histone cluster 1, H2aa". 

Further reading[edit]