HIST1H2AA

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Histone cluster 1, H2aa
Protein HIST1H2AA PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2AA ; H2AA; H2AFR; bA317E16.2
External IDs OMIM613499 HomoloGene108269 GeneCards: HIST1H2AA Gene
RNA expression pattern
PBB GE HIST1H2AA gnf1h05799 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 221613 319163
Ensembl ENSG00000164508 ENSMUSG00000060081
UniProt Q96QV6 Q8CGP4
RefSeq (mRNA) NM_170745 NM_175658.1
RefSeq (protein) NP_734466 NP_783589.1
Location (UCSC) Chr 6:
25.73 – 25.73 Mb
Chr 13:
24.03 – 24.03 Mb
PubMed search [1] [2]

Histone H2A type 1-A is a protein that in humans is encoded by the HIST1H2AA gene.[1][2]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.[2]

References[edit]

  1. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  2. ^ a b "Entrez Gene: HIST1H2AA histone cluster 1, H2aa". 

Further reading[edit]