HIST1H2AB

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Histone cluster 1, H2ab
Protein HIST1H2AB PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2AB ; H2A/m; H2AFM
External IDs OMIM602795 MGI2448287 HomoloGene133091 GeneCards: HIST1H2AB Gene
Orthologs
Species Human Mouse
Entrez 8335 319173
Ensembl ENSG00000137259 ENSMUSG00000061991
UniProt P04908 Q8CGP5
RefSeq (mRNA) NM_003513 NM_175661
RefSeq (protein) NP_003504 NP_783592
Location (UCSC) Chr 6:
26.03 – 26.03 Mb
Chr 13:
23.53 – 23.53 Mb
PubMed search [1] [2]

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AB gene.[1][2][3][4]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[4]

References[edit]

  1. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  2. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H2AB histone cluster 1, H2ab". 

Further reading[edit]