HIST1H2AC

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Histone cluster 1, H2ac
Protein HIST1H2AC PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2AC ; H2A/l; H2AFL; dJ221C16.4
External IDs OMIM602794 MGI2448285 HomoloGene130459 GeneCards: HIST1H2AC Gene
RNA expression pattern
PBB GE HIST1H2AC 215071 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8334 319163
Ensembl ENSG00000180573 ENSMUSG00000060081
UniProt Q93077 Q8CGP4
RefSeq (mRNA) NM_003512 NM_175658
RefSeq (protein) NP_003503 NP_783589
Location (UCSC) Chr 6:
26.12 – 26.14 Mb
Chr 13:
23.93 – 23.93 Mb
PubMed search [1] [2]

Histone H2A type 1-C is a protein that in humans is encoded by the HIST1H2AC gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]

References[edit]

  1. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2AC histone cluster 1, H2ac". 

Further reading[edit]