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Histone cluster 1, H2ad
Protein HIST1H2AD PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H2AD ; H2A.3; H2A/g; H2AFG
External IDs OMIM602792 HomoloGene108182 GeneCards: HIST1H2AD Gene
RNA expression pattern
PBB GE HIST1H2AD 214522 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3013 319169
Ensembl ENSG00000196866 ENSMUSG00000063021
UniProt P20671 Q8CGP7
RefSeq (mRNA) NM_021065 NM_178183
RefSeq (protein) NP_066409 NP_835490
Location (UCSC) Chr 6:
26.2 – 26.2 Mb
Chr 13:
21.75 – 21.75 Mb
PubMed search [1] [2]

Histone H2A type 1-D is a protein that in humans is encoded by the HIST1H2AD gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[3]


  1. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2AD histone cluster 1, H2ad". 

Further reading[edit]