HIST1H2AE

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Histone cluster 1, H2ae
Protein HIST1H2AE PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2AE ; H2A.1; H2A.2; H2A/a; H2AFA
External IDs OMIM602786 MGI2448309 HomoloGene135791 GeneCards: HIST1H2AE Gene
Orthologs
Species Human Mouse
Entrez 3012 319191
Ensembl ENSG00000137259 ENSMUSG00000061615
UniProt P04908 P22752
RefSeq (mRNA) NM_021052 NM_178182
RefSeq (protein) NP_066390 NP_835489
Location (UCSC) Chr 6:
26.03 – 26.03 Mb
Chr 13:
21.72 – 21.72 Mb
PubMed search [1] [2]

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AE gene.[1][2][3][4]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[4]

References[edit]

  1. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  2. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H2AE histone cluster 1, H2ae". 

Further reading[edit]