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Histone cluster 1, H2ag
Protein HIST1H2AG PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H2AG ; H2A.1b; H2A/p; H2AFP; H2AG; pH2A/f
External IDs OMIM615012 MGI2448297 HomoloGene137349 GeneCards: HIST1H2AG Gene
Species Human Mouse
Entrez 8969 319170
Ensembl ENSG00000184348 ENSMUSG00000061615
UniProt P0C0S8 P22752
RefSeq (mRNA) NM_021064 NM_178184
RefSeq (protein) NP_066408 NP_835491
Location (UCSC) Chr 6:
27.1 – 27.1 Mb
Chr 13:
21.72 – 21.72 Mb
PubMed search [1] [2]

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AG gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.[3]


  1. ^ Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W (Jun 1994). "The relative expression of human histone H2A genes is similar in different types of proliferating cells". DNA Cell Biol 13 (2): 161–70. doi:10.1089/dna.1994.13.161. PMID 8179821. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2AG histone cluster 1, H2ag". 

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