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Histone cluster 1, H2ai
Protein HIST1H2AI PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H2AI ; H2A/c; H2AFC
External IDs OMIM602787 HomoloGene134476 GeneCards: HIST1H2AI Gene
Species Human Mouse
Entrez 8329 319168
Ensembl ENSG00000184348 ENSMUSG00000061615
UniProt P0C0S8 Q8CGP6
RefSeq (mRNA) NM_003509 NM_175659
RefSeq (protein) NP_003500 NP_783590
Location (UCSC) Chr 6:
27.1 – 27.1 Mb
Chr 13:
21.72 – 21.72 Mb
PubMed search [1] [2]

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AI gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[3]


  1. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2AI histone cluster 1, H2ai". 

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