HIST1H2BA

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Histone cluster 1, H2ba
PBB Protein HIST1H2BA image.jpg
PDB rendering based on 1hio.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2BA ; H2BFU; STBP; TSH2B; TSH2B.1; bA317E16.3
External IDs OMIM609904 MGI2448375 HomoloGene69356 GeneCards: HIST1H2BA Gene
Orthologs
Species Human Mouse
Entrez 255626 319177
Ensembl ENSG00000146047 ENSMUSG00000050799
UniProt Q96A08 P70696
RefSeq (mRNA) NM_170610 NM_175663
RefSeq (protein) NP_733759 NP_783594
Location (UCSC) Chr 6:
25.73 – 25.73 Mb
Chr 13:
23.93 – 23.93 Mb
PubMed search [1] [2]

Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.[3]

References[edit]

  1. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  2. ^ Zalensky AO, Siino JS, Gineitis AA, Zalenskaya IA, Tomilin NV, Yau P, Bradbury EM (Nov 2002). "Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization". J Biol Chem 277 (45): 43474–80. doi:10.1074/jbc.M206065200. PMID 12213818. 
  3. ^ a b "Entrez Gene: HIST1H2BA histone cluster 1, H2ba". 

Further reading[edit]