HIST1H2BB

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Histone cluster 1, H2bb
Protein HIST1H2BB PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2BB ; H2B.1; H2B/f; H2BFF
External IDs OMIM602803 MGI2448377 HomoloGene121970 GeneCards: HIST1H2BB Gene
RNA expression pattern
PBB GE HIST1H2BB 208547 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3018 319178
Ensembl ENSG00000196226 ENSMUSG00000075031
UniProt P33778 Q64475
RefSeq (mRNA) NM_021062 NM_175664
RefSeq (protein) NP_066406 NP_783595
Location (UCSC) Chr 6:
26.04 – 26.04 Mb
Chr 13:
23.75 – 23.75 Mb
PubMed search [1] [2]

Histone H2B type 1-B is a protein that in humans is encoded by the HIST1H2BB gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[3]

References[edit]

  1. ^ Kardalinou E, Eick S, Albig W, Doenecke D (Dec 1993). "Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones". J Cell Biochem 52 (4): 375–83. doi:10.1002/jcb.240520402. PMID 8227173. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2BB histone cluster 1, H2bb". 

Further reading[edit]