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Histone cluster 1, H2bb
Protein HIST1H2BB PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H2BB ; H2B.1; H2B/f; H2BFF
External IDs OMIM602803 MGI2448377 HomoloGene137348 GeneCards: HIST1H2BB Gene
RNA expression pattern
PBB GE HIST1H2BB 208547 at tn.png
More reference expression data
Species Human Mouse
Entrez 3018 319178
Ensembl ENSG00000196226 ENSMUSG00000075031
UniProt P33778 Q64475
RefSeq (mRNA) NM_021062 NM_175664
RefSeq (protein) NP_066406 NP_783595
Location (UCSC) Chr 6:
26.04 – 26.04 Mb
Chr 13:
23.75 – 23.75 Mb
PubMed search [1] [2]

Histone H2B type 1-B is a protein that in humans is encoded by the HIST1H2BB gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[3]


  1. ^ Kardalinou E, Eick S, Albig W, Doenecke D (Dec 1993). "Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones". J Cell Biochem 52 (4): 375–83. doi:10.1002/jcb.240520402. PMID 8227173. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2BB histone cluster 1, H2bb". 

Further reading[edit]