HIST1H2BD

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Histone cluster 1, H2bd
Protein HIST1H2BD PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2BD ; H2B.1B; H2B/b; H2BFB; HIRIP2; dJ221C16.6
External IDs OMIM602799 MGI2448409 HomoloGene134740 GeneCards: HIST1H2BD Gene
RNA expression pattern
PBB GE HIST1H1E 222067 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3017 78303
Ensembl ENSG00000158373 ENSMUSG00000056895
UniProt P58876 Q9D2U9
RefSeq (mRNA) NM_021063 NM_030082
RefSeq (protein) NP_066407 NP_084358
Location (UCSC) Chr 6:
26.16 – 26.17 Mb
Chr 11:
58.95 – 58.95 Mb
PubMed search [1] [2]

Histone H2B type 1-D is a protein that in humans is encoded by the HIST1H2BD gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3.[3]

References[edit]

  1. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2BD histone cluster 1, H2bd". 

Further reading[edit]