HIST1H2BG

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Histone cluster 1, H2bg
Protein HIST1H2BG PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2BG ; H2B.1A; H2B/a; H2BFA; dJ221C16.8
External IDs OMIM602798 MGI2448404 HomoloGene130120 GeneCards: HIST1H2BG Gene
Orthologs
Species Human Mouse
Entrez 8339 68024
Ensembl ENSG00000168242 ENSMUSG00000018102
UniProt P62807 Q6ZWY9
RefSeq (mRNA) NM_003518 NM_023422
RefSeq (protein) NP_003509 NP_075911
Location (UCSC) Chr 6:
26.12 – 26.12 Mb
Chr 13:
23.57 – 23.57 Mb
PubMed search [1] [2]

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BG gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[3]

References[edit]

  1. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2BG histone cluster 1, H2bg". 

Further reading[edit]