HIST1H2BH

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Histone cluster 1, H2bh
Protein HIST1H2BH PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2BH ; H2B/j; H2BFJ
External IDs OMIM602806 HomoloGene128594 GeneCards: HIST1H2BH Gene
RNA expression pattern
PBB GE HIST1H2BH 208546 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8345 319182
Ensembl ENSG00000197459 ENSMUSG00000064168
UniProt Q93079 Q64478
RefSeq (mRNA) NM_003524 NM_178197
RefSeq (protein) NP_003515 NP_835504
Location (UCSC) Chr 6:
26.25 – 26.25 Mb
Chr 13:
23.54 – 23.54 Mb
PubMed search [1] [2]

Histone H2B type 1-H is a protein that in humans is encoded by the HIST1H2BH gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]

References[edit]

  1. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2BH histone cluster 1, H2bh". 

Further reading[edit]