HIST1H2BJ

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Histone cluster 1, H2bj
Protein HIST1H2BJ PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2BJ ; H2B/r; H2BFR; H2BJ
External IDs OMIM615044 HomoloGene128594 GeneCards: HIST1H2BJ Gene
Orthologs
Species Human Mouse
Entrez 8970 319190
Ensembl ENSG00000124635 ENSMUSG00000068854
UniProt P06899 Q64524
RefSeq (mRNA) NM_021058 NM_178214
RefSeq (protein) NP_066402 NP_835586
Location (UCSC) Chr 6:
27.09 – 27.1 Mb
Chr 3:
96.22 – 96.22 Mb
PubMed search [1] [2]

Histone H2B type 1-J is a protein that in humans is encoded by the HIST1H2BJ gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.[3]

References[edit]

  1. ^ Zhong R, Roeder RG, Heintz N (Jan 1984). "The primary structure and expression of four cloned human histone genes". Nucleic Acids Res 11 (21): 7409–7425. doi:10.1093/nar/11.21.7409. PMC 326492. PMID 6647026. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2BJ histone cluster 1, H2bj". 

Further reading[edit]