HIST1H2BL

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Histone cluster 1, H2bl
Protein HIST1H2BL PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2BL ; H2B/c; H2BFC; dJ97D16.4
External IDs OMIM602800 MGI2448415 HomoloGene130521 GeneCards: HIST1H2BL Gene
RNA expression pattern
PBB GE HIST1H2BL 207611 at tn.png
PBB GE HIST1H2BL 208527 x at tn.png
PBB GE HIST1H2BL 208579 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8340 319180
Ensembl ENSG00000185130 ENSMUSG00000069268
UniProt Q99880 P10853
RefSeq (mRNA) NM_003519 NM_178195
RefSeq (protein) NP_003510 NP_835502
Location (UCSC) Chr 6:
27.78 – 27.78 Mb
Chr 13:
21.72 – 21.72 Mb
PubMed search [1] [2]

Histone H2B type 1-L is a protein that in humans is encoded by the HIST1H2BL gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[3]

References[edit]

  1. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2BL histone cluster 1, H2bl". 

Further reading[edit]