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Histone cluster 1, H2bo
Protein HIST1H2BO PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H2BO ; H2B.2; H2B/n; H2BFN; dJ193B12.2
External IDs OMIM602808 HomoloGene134442 GeneCards: HIST1H2BO Gene
RNA expression pattern
PBB GE HIST1H2BO 214540 at tn.png
More reference expression data
Species Human Mouse
Entrez 8348 319188
Ensembl ENSG00000196331 ENSMUSG00000069308
UniProt P23527 Q8CGP2
RefSeq (mRNA) NM_003527 NM_001290466
RefSeq (protein) NP_003518 NP_001277395
Location (UCSC) Chr 6:
27.86 – 27.86 Mb
Chr 13:
21.79 – 21.79 Mb
PubMed search [1] [2]

Histone H2B type 1-O is a protein that in humans is encoded by the HIST1H2BO gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[3]


  1. ^ Dobner T, Wolf I, Mai B, Lipp M (Feb 1992). "A novel divergently transcribed human histone H2A/H2B gene pair". DNA Seq 1 (6): 409–13. doi:10.3109/10425179109020799. PMID 1768865. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2BO histone cluster 1, H2bo". 

Further reading[edit]