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Histone cluster 1, H3b
Protein HIST1H3B PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H3B ; H3/l; H3FL
External IDs OMIM602819 MGI2145541 HomoloGene136775 GeneCards: HIST1H3B Gene
Species Human Mouse
Entrez 8358 319154
Ensembl ENSG00000124693 ENSMUSG00000059309
UniProt P68431 P84228
RefSeq (mRNA) NM_003537 NM_178215
RefSeq (protein) NP_003528 NP_835587
Location (UCSC) Chr 6:
26.02 – 26.02 Mb
Chr 13:
23.54 – 23.55 Mb
PubMed search [1] [2]

Histone H3.1 is a protein that in humans is encoded by the HIST1H3B gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[4]


  1. ^ Zhong R, Roeder RG, Heintz N (Jan 1984). "The primary structure and expression of four cloned human histone genes". Nucleic Acids Res 11 (21): 7409–25. doi:10.1093/nar/11.21.7409. PMC 326492. PMID 6647026. 
  2. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ "Entrez Gene: HIST1H3B histone cluster 1, H3b". 

Further reading[edit]