HIST1H3E

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Histone cluster 1, H3e
Protein HIST1H3E PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H3E ; H3.1; H3/d; H3FD
External IDs OMIM602813 HomoloGene134113 GeneCards: HIST1H3E Gene
Orthologs
Species Human Mouse
Entrez 8353 319152
Ensembl ENSG00000124693 ENSMUSG00000062417
UniProt P68431 P68433
RefSeq (mRNA) NM_003532 NM_178206
RefSeq (protein) NP_003523 NP_835513
Location (UCSC) Chr 6:
26.02 – 26.02 Mb
Chr 13:
21.72 – 21.72 Mb
PubMed search [1] [2]

Histone H3.1 is a protein that in humans is encoded by the HIST1H3E gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]

References[edit]

  1. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H3E histone cluster 1, H3e". 

Further reading[edit]