HIST1H4B

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Histone cluster 1, H4b
Protein HIST1H4B PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H4B ; H4/I; H4FI
External IDs OMIM602829 MGI2448427 HomoloGene134493 GeneCards: HIST1H4B Gene
Orthologs
Species Human Mouse
Entrez 8366 320332
Ensembl ENSG00000124529 ENSMUSG00000060093
UniProt P62805 P62806
RefSeq (mRNA) NM_003544 NM_175652
RefSeq (protein) NP_003535 NP_783583
Location (UCSC) Chr 1:
149.8 – 149.81 Mb
Chr 13:
21.74 – 21.74 Mb
PubMed search [1] [2]

Histone H4 is a protein that in humans is encoded by the HIST1H4B gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 147 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]

References[edit]

  1. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–322. doi:10.1006/geno.1996.4592. PMID 9119399. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H4B histone cluster 1, H4b". 

Further reading[edit]