HIST1H4C

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Histone cluster 1, H4c
Protein HIST1H4C PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H4C ; H4/g; H4FG; dJ221C16.1
External IDs OMIM602827 MGI2448420 HomoloGene134234 GeneCards: HIST1H4C Gene
Orthologs
Species Human Mouse
Entrez 8364 97122
Ensembl ENSG00000124529 ENSMUSG00000060093
UniProt P62805 P62806
RefSeq (mRNA) NM_003542 NM_033596
RefSeq (protein) NP_003533 NP_291074
Location (UCSC) Chr 1:
149.8 – 149.81 Mb
Chr 13:
21.74 – 21.74 Mb
PubMed search [1] [2]

Histone H4 is a protein that in humans is encoded by the HIST1H4C gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]

References[edit]

  1. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H4C histone cluster 1, H4c". 

Further reading[edit]