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Histone cluster 1, H4g
Symbols HIST1H4G ; H4/l; H4FL
External IDs OMIM602832 HomoloGene48222 GeneCards: HIST1H4G Gene
RNA expression pattern
PBB GE HIST1H4G 208551 at tn.png
More reference expression data
Species Human Mouse
Entrez 8369 n/a
Ensembl ENSG00000124578 n/a
UniProt Q99525 n/a
RefSeq (mRNA) NM_003547 n/a
RefSeq (protein) NP_003538 n/a
Location (UCSC) Chr 6:
26.25 – 26.25 Mb
PubMed search [1] n/a

Histone H4-like protein type G is a protein that in humans is encoded by the HIST1H4G gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]


  1. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H4G histone cluster 1, H4g". 

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