HIST1H4I

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Histone cluster 1, H4i
Protein HIST1H4I PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H4I ; H4/m; H4FM; H4M
External IDs OMIM602833 MGI2448425 HomoloGene134482 GeneCards: HIST1H4I Gene
Orthologs
Species Human Mouse
Entrez 8294 69386
Ensembl ENSG00000124529 ENSMUSG00000060093
UniProt P62805 P62806
RefSeq (mRNA) NM_003495 NM_153173
RefSeq (protein) NP_003486 NP_694813
Location (UCSC) Chr 1:
149.8 – 149.81 Mb
Chr 13:
21.74 – 21.74 Mb
PubMed search [1] [2]

Histone H4 is a protein that, in humans, is encoded by the HIST1H4I gene.[1][2][3][4]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.[4]

References[edit]

  1. ^ Akasaka T, Miura I, Takahashi N, Akasaka H, Yonetani N, Ohno H, Fukuhara S, Okuma M (Jan 1997). "A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5' regulatory region of BCL6 with a novel H4 histone gene". Cancer Res 57 (1): 7–12. PMID 8988030. 
  2. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H4I histone cluster 1, H4i". 

Further reading[edit]