HIST1H4K

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Histone cluster 1, H4k
Protein HIST1H4K PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H4K ; H4/d; H4F2iii; H4FD; dJ160A22.1
External IDs OMIM602825 MGI2448423 HomoloGene133102 GeneCards: HIST1H4K Gene
Orthologs
Species Human Mouse
Entrez 8362 319156
Ensembl ENSG00000124529 n/a
UniProt P62805 n/a
RefSeq (mRNA) NM_003541 NM_175654
RefSeq (protein) NP_003532 NP_783585
Location (UCSC) Chr 1:
149.8 – 149.81 Mb
n/a
PubMed search [1] [2]

Histone H4 is a protein that in humans is encoded by the HIST1H4K gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[3]

References[edit]

  1. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H4K histone cluster 1, H4k". 

Further reading[edit]