HIST1H4L

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Histone cluster 1, H4l
Protein HIST1H4L PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H4L ; H4.k; H4/k; H4FK
External IDs OMIM602831 MGI2140113 HomoloGene136248 GeneCards: HIST1H4L Gene
Orthologs
Species Human Mouse
Entrez 8368 319161
Ensembl ENSG00000124529 ENSMUSG00000060093
UniProt P62805 P62806
RefSeq (mRNA) NM_003546 NM_175657
RefSeq (protein) NP_003537 NP_783588
Location (UCSC) Chr 1:
149.8 – 149.81 Mb
Chr 13:
21.74 – 21.74 Mb
PubMed search [1] [2]

Histone H4 is a protein that in humans is encoded by the HIST1H4L gene.[1][2][3][4]

Function[edit]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[4]

References[edit]

  1. ^ Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620. 
  2. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H4L histone cluster 1, H4l". 

Further reading[edit]