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Histone cluster 2, H2aa3
Protein HIST2H2AA3 PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST2H2AA3 ; H2A; H2A.2; H2A/O; H2A/q; H2AFO; H2a-615; HIST2H2AA
External IDs OMIM142720 MGI96097 HomoloGene116071 GeneCards: HIST2H2AA3 Gene
Species Human Mouse
Entrez 8337 15267
Ensembl ENSG00000183558 ENSMUSG00000063954
UniProt Q6FI13 Q6GSS7
RefSeq (mRNA) NM_003516 NM_013549
RefSeq (protein) NP_003507 NP_038577
Location (UCSC) Chr 1:
149.81 – 149.81 Mb
Chr 3:
96.24 – 96.24 Mb
PubMed search [1] [2]

Histone H2A type 2-A is a protein that in humans is encoded by the HIST2H2AA3 gene.[1][2][3][4]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.[4]


  1. ^ Marashi F, Prokopp K, Stein J, Stein G (May 1984). "Evidence for a human histone gene cluster containing H2B and H2A pseudogenes". Proc Natl Acad Sci U S A 81 (7): 1936–40. doi:10.1073/pnas.81.7.1936. PMC 345411. PMID 6326092. 
  2. ^ Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W (Jun 1994). "The relative expression of human histone H2A genes is similar in different types of proliferating cells". DNA Cell Biol 13 (2): 161–70. doi:10.1089/dna.1994.13.161. PMID 8179821. 
  3. ^ Braastad CD, Hovhannisyan H, van Wijnen AJ, Stein JL, Stein GS (Nov 2004). "Functional characterization of a human histone gene cluster duplication". Gene 342 (1): 35–40. doi:10.1016/j.gene.2004.07.036. PMID 15527963. 
  4. ^ a b "Entrez Gene: HIST2H2AA3 histone cluster 2, H2aa3". 

Further reading[edit]