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Histone cluster 2, H3c
Protein HIST2H3C PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST2H3C ; H3; H3.2; H3/M; H3F2; H3FM; H3FN
External IDs OMIM142780 MGI2448355 HomoloGene134475 GeneCards: HIST2H3C Gene
Species Human Mouse
Entrez 126961 625328
Ensembl ENSG00000183598 ENSMUSG00000016559
UniProt Q71DI3 P02301
RefSeq (mRNA) NM_021059 NM_178216
RefSeq (protein) NP_066403 NP_835734
Location (UCSC) Chr 1:
149.78 – 149.79 Mb
Chr 1:
180.8 – 180.81 Mb
PubMed search [1] [2]

Histone H3.2 is a protein that in humans is encoded by the HIST2H3C gene.[1][2][3]


Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy.[3]


HIST2H3C has been shown to interact with NCOA6.[4]


  1. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  2. ^ Marashi F, Helms S, Shiels A, Silverstein S, Greenspan DS, Stein G et al. (Jul 1986). "Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences". Biochem Cell Biol 64 (4): 277–289. doi:10.1139/o86-039. PMID 3013246. 
  3. ^ a b "Entrez Gene: HIST2H3C histone cluster 2, H3c". 
  4. ^ Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ et al. (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. 23 (1): 140–149. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670. PMID 12482968. 

Further reading[edit]