HIST3H3

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Histone cluster 3, H3
Protein HIST3H3 PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST3H3 ; H3.4; H3/g; H3FT; H3t
External IDs OMIM602820 HomoloGene133212 GeneCards: HIST3H3 Gene
RNA expression pattern
PBB GE HIST3H3 208572 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8290 623365
Ensembl ENSG00000168148 ENSMUSG00000062417
UniProt Q16695 P68433
RefSeq (mRNA) NM_003493 NM_145073.2
RefSeq (protein) NP_003484 NP_659539.1
Location (UCSC) Chr 1:
228.61 – 228.61 Mb
Chr 13:
21.81 – 21.81 Mb
PubMed search [1] [2]

Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene.[1][2]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.[3]

References[edit]

  1. ^ Albig W, Ebentheuer J, Klobeck G, Kunz J, Doenecke D (Dec 1996). "A solitary human H3 histone gene on chromosome 1". Hum Genet 97 (4): 486–91. doi:10.1007/BF02267072. PMID 8834248. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ "Entrez Gene: HIST3H3 histone cluster 3, H3". 

Further reading[edit]