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Histone cluster 4, H4
Protein HIST4H4 PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST4H4 ; H4/p
External IDs OMIM615069 MGI2448436 HomoloGene133102 ChEMBL: 5876 GeneCards: HIST4H4 Gene
Species Human Mouse
Entrez 121504 319159
Ensembl ENSG00000124529 n/a
UniProt P62805 n/a
RefSeq (mRNA) NM_175054 NM_178210
RefSeq (protein) NP_778224 NP_835582
Location (UCSC) Chr 1:
149.8 – 149.81 Mb
PubMed search [1] [2]

Histone H4 is a protein that in humans is encoded by the HIST4H4 gene.[1]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.[2]


  1. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  2. ^ "Entrez Gene: HIST4H4 histone cluster 4, H4". 

Further reading[edit]