HK2

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Hexokinase 2
PDB 2nzt EBI.png
PDB rendering based on 2nzt.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HK2 ; HKII; HXK2
External IDs OMIM601125 MGI1315197 HomoloGene37273 ChEMBL: 2640 GeneCards: HK2 Gene
EC number 2.7.1.1
Orthologs
Species Human Mouse
Entrez 3099 15277
Ensembl ENSG00000159399 ENSMUSG00000000628
UniProt P52789 O08528
RefSeq (mRNA) NM_000189 NM_013820
RefSeq (protein) NP_000180 NP_038848
Location (UCSC) Chr 2:
75.06 – 75.12 Mb
Chr 6:
82.73 – 82.77 Mb
PubMed search [1] [2]

Hexokinase 2 also known as HK2 is an enzyme which in humans is encoded by the HK2 gene.[1]

Function[edit]

Hexokinases phosphorylate glucose to produce glucose 6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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Glycolysis and Gluconeogenesis edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534". 

References[edit]

  1. ^ Lehto M, Xiang K, Stoffel M, Espinosa R, Groop LC, Le Beau MM, Bell GI (December 1993). "Human hexokinase II: localization of the polymorphic gene to chromosome 2". Diabetologia 36 (12): 1299–302. doi:10.1007/BF00400809. PMID 8307259. 
  2. ^ "Entrez Gene: HK2 hexokinase 2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.