HLA-B35

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Computer illustration of HLA-B*3508 with EBV (EPLPQGQLTAY) in the binding pocket.
B*3508-β2MG with bound peptide
2h6p
major histocompatibility complex (human), class I, B35
Alleles B*3501, 3502, 3503, . . .
Structure (See HLA-B)
Symbol(s) HLA-B 2fyy, 2fz3
EBI-HLA B*3501 2h6p, 2cik,
1a1n
EBI-HLA B*3502
EBI-HLA B*3503
EBI-HLA B*3504
EBI-HLA B*3505
EBI-HLA B*3506
EBI-HLA B*3507
EBI-HLA B*3508 2nw3, 2nx5
EBI-HLA B*3509
EBI-HLA B*3510
EBI-HLA B*3511
EBI-HLA B*3512
Locus chr.6 6p21.31

HLA-B35 (B35) is an HLA-B serotype. The serotype identifies the more common HLA-B*35 gene products.[1] B35 is one of the largest B serotype groups, it currently has 97 known nucleotide variants and 86 polypeptide isoforms. (For terminology help see: HLA-serotype tutorial). This variant is particularly susceptible to HIV infection.

Serotype[edit]

B35 serotype recognition of Some HLA B*35 allele-group gene products[2]
B*35 B35 Sample
allele  %  % size (N)
3501 98 2023
3502 72 1013
3503 94 1226
3504 100 26
3505 94 231
3506 79 10
3508 91 349
3509 68 3
3510 75 12
3511 67 17
3512 78 422
3514 79 29
3520 42 23

References[edit]

  1. ^ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. 
  2. ^ derived from IMGT/HLA