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Major histocompatibility complex, class II, DO alpha
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM142930 MGI95924 HomoloGene1601 GeneCards: HLA-DOA Gene
RNA expression pattern
PBB GE HLA-DOA 206313 at tn.png
PBB GE HLA-DOA 211142 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3111 15001
Ensembl ENSG00000204252 ENSMUSG00000024334
UniProt P06340 Q9QWV1
RefSeq (mRNA) NM_002119 NM_008206
RefSeq (protein) NP_002110 NP_032232
Location (UCSC) Chr 6:
32.97 – 32.98 Mb
Chr 17:
34.09 – 34.1 Mb
PubMed search [1] [2]

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.[1][2]

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.[2]


  1. ^ Young JA, Trowsdale J (Aug 1990). "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript". Immunogenetics 31 (5–6): 386–8. doi:10.1007/BF02115015. PMID 2370084. 
  2. ^ a b "Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha". 

Further reading[edit]