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Major histocompatibility complex, class II, DO beta
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HLA-DOB ; DOB
External IDs OMIM600629 MGI95925 HomoloGene1602 GeneCards: HLA-DOB Gene
RNA expression pattern
PBB GE HLA-DOB 205671 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3112 15002
Ensembl ENSG00000239457 ENSMUSG00000041538
UniProt P13765 E9Q479
RefSeq (mRNA) NM_002120 NM_010389
RefSeq (protein) NP_002111 NP_034519
Location (UCSC) Chr 6:
32.78 – 32.78 Mb
Chr 17:
34.24 – 34.25 Mb
PubMed search [1] [2]

HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene.[1]

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.[1]


Further reading[edit]