HLA-DR11

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR11
Haplotypes groups DQA*01:DRB1*1101 to DQA*01:DRB1*1111
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *1101 to *1110
Symbol(s) HLA-DRB1
EBI-HLA DRB1*1101
EBI-HLA DRB1*1102
EBI-HLA DRB1*1103
EBI-HLA DRB1*1104
EBI-HLA DRB1*1105
EBI-HLA DRB1*1106
Shared data
Locus chr.6 6p21.31

HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.

Serology[edit]

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 alleles[1]
DRB1* DR11 DR5 DR12 Sample
allele  %  %  % size (N)
1101 92 5 3474
1102 89 3 430
1103 89 4 397
1104 87 4 2119
1105 75 4
1106 20 73 15
1107 >50 1
1108 >50 2
1109 80 20 5

The table above describes the efficiency of serological typing of DR11 and DR5. Serotypes are unknown the following alleles: DRB1*1110 to *1157

Disease associations[edit]

By serotype[edit]

DR11 is associated with grape anaphylaxis,[2] well-differentiated thyroid cancer,[3] low antibody production in Hepatitis C.[4]

By allele(s)[edit]

DRB1*11 is associated systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody [5]

DRB1*1101 is associated Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus,[6] mite sensitive asthma,[7] cervical cancer risk (HPV?)[8]

DRB1*1102: Tiopronin intolerance in rheumatoid arthritis[9]

DRB1*1104: pauciarticular juvenile rheumatoid arthritis [10]

By haplotype[edit]

DR11 is an identifyer for the DR11-DQ7/DR7-DQ2 transhaplotype isoform of celiac disease.[11] DR11-DQ7.5 is identified as a risk factor in rheumatic heart disease.[12]

DRB1*1101:DQA1*0505:DQB1*0301 haplotype is associated with Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus,[6] mite sensitive asthma[7]

DRB1*1102:DQA1*0505:DQB1*0301 haplotype is associated with hepatitis B virus persistence[13]

Genetic Linkage[edit]

DR11 Haplotypes
Serotypes DRA DRB1 DRB3
DR11(5)-DR52 *0101 *1101 *02
*0101 *1102 *02
*0101 *1103 *02
*0101 *1104 *02
Serotypes DRB1 DQA1 DQB1
DR11(5)-DQ7 (7.5, 3) *1101 *0505 *0301
*1102 *0505 *0301
*1103 *0505 *0301
*1104 *0505 *0301
Serotypes HLA-A HLA-C HLA-B DRB1
A2-Cw7-B18-DR11 *0201 *0701 *1801 *1104
A24(9)-Cw4-B35-DR11 *2402 *0401 *3501 *1101
A24(9)-Cw14(BL)-B51(5)-DR11 *2402 *1402 *5101 *1104

HLA-DR11 is genetically linked to HLA-DR52 and HLA-DQ7(3) serotypes. The frequency node for DR11 is in the Levant and Anatolia. This serotype more than others appears to have spread with neolithization of Western Europe. The closely linked DQ7.5 appears to be protective against juvenile diabetes, in which wheat consumption appears to be a risk factor.

References[edit]

  1. ^ derived from IMGT/HLA
  2. ^ Kalogeromitros D, Makris M, Gregoriou S, Mousatou V, Lyris N, Tarassi K, Papasteriades C (2005). "Grape anaphylaxis: a study of 11 adult onset cases.". Allergy Asthma Proc 26 (1): 53–8. PMID 15813289. 
  3. ^ Juhasz F, Kozma L, Stenszky V, Gyory F, Luckas G, Farid N (2005). "Well differentiated thyroid carcinoma is associated with human lymphocyte antigen D-related 11 in Eastern Hungarians: a case of changing circumstances.". Cancer 104 (8): 1603–8. doi:10.1002/cncr.21382. PMID 16121403. 
  4. ^ Hu C, Wu C, Lee C, Wu C, Tsai H, Chen P, Hsu P (2006). "HLA-DR11 and HLA-DR2 are negatively associated with autoantibody production in chronic hepatitis C.". Ann Rheum Dis 65 (1): 138–9. doi:10.1136/ard.2005.039982. PMC 1797994. PMID 16344504. 
  5. ^ Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody.". Arthritis Rheum 42 (3): 465–74. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769. 
  6. ^ a b Miyagawa S, Shinohara K, Kidoguchi K, Fujita T, Fukumoto T, Hashimoto K, Yoshioka A, Shirai T (1997). "Neonatal lupus erythematosus: studies on HLA class II genes and autoantibody profiles in Japanese mothers.". Autoimmunity 26 (2): 95–101. doi:10.3109/08916939709003852. PMID 9546818. 
  7. ^ a b Lara-Marquez M, Yunis J, Layrisse Z, Ortega F, Carvallo-Gil E, Montagnani S, Makhatadze N, Pocino M, Granja C, Yunis E (1999). "Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population.". Clin Exp Allergy 29 (1): 60–71. doi:10.1046/j.1365-2222.1999.00461.x. PMID 10051703. 
  8. ^ Madeleine M, Brumback B, Cushing-Haugen K, Schwartz S, Daling J, Smith A, Nelson J, Porter P, Shera K, McDougall J, Galloway D (2002). "Human leukocyte antigen class II and cervical cancer risk: a population-based study.". J Infect Dis 186 (11): 1565–74. doi:10.1086/345285. PMID 12447731. 
  9. ^ Ju L, Paolozzi L, Delecoeuillerie G, Bourgeois P, Khodja M, Legoff P, Liote F, Sheffer V, Amor B, Charron D (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis.". Clin Exp Rheumatol 12 (3): 249–54. PMID 7915222. 
  10. ^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.". Hum Immunol 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191. 
  11. ^ Tighe M, Hall M, Barbado M, Cardi E, Welsh K, Ciclitira P (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population.". Tissue Antigens 40 (2): 90–7. doi:10.1111/j.1399-0039.1992.tb01965.x. PMID 1357780. 
  12. ^ Chou HT, Chen CH, Chen JY, Chang KC (2007). "Association of HLA DRB1-DQA1-DQB1 haplotypes with rheumatic heart disease in Taiwan". International Journal of Cardiology 128 (3): 434. doi:10.1016/j.ijcard.2007.06.032. PMID 17673320. 
  13. ^ Thio C, Carrington M, Marti D, O'Brien S, Vlahov D, Nelson K, Astemborski J, Thomas D (1999). "Class II HLA alleles and hepatitis B virus persistence in African Americans.". J Infect Dis 179 (4): 1004–6. doi:10.1086/314684. PMID 10068598.