HLA-DR15
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major histocompatibility complex, class II, DR15
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| Haplotypes groups | DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507 |
| Structure (See HLA-DR) | |
| Identifiers |
alpha *0101
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| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers |
beta 1 *1501 to *1505 *1507
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| Symbol(s) | HLA-DRB1 |
| EBI-HLA | DRB1*1501 |
| EBI-HLA | DRB1*1502 |
| EBI-HLA | DRB1*1503 |
| EBI-HLA | DRB1*1504 |
| EBI-HLA | DRB1*1505 |
| EBI-HLA | DRB1*1507 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. frequencies. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.
Contents |
[edit] Serology
| DRB1* | DR15 | DR2 | DR16 | Sample |
| allele | % | % | % | size (N) |
| 1501 | 76 | 23 | 6428 | |
| 1502 | 77 | 16 | 676 | |
| 1503 | 81 | 13 | 286 | |
| 1504 | >50 | 1 | ||
| 1505 | >25 | 2 | ||
| 1507 | >50 | 1 |
Serotypes are unknown the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.
[edit] Alleles
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[edit] Disease associations
DR15 is positively associated Goodpasture syndrome[2], early age onset multiple sclerosis[3], pernicious anaemia,[4] sarcoidosis,[5] hypocretin deficiency associated narcolepsy[6][7] and a predisposition for postmenopausal osteoporosis.[8]
DRB1*1501 is positively associated with Goodpasture syndrome[9][10], juvenile rheumatoid arthritis[11], allergic bronchopulmonary aspergillosis[12], multiple sclerosis[13], systemic lupus erythematosus[14], cervical cancer (human papillomavirus infection)[15], and Sjogren's syndrome associated with systemic lupus erythematosus.[16]
DRB1*1502 is associated with systemic lupus erythematosus[17], systemic sclerosis (SSc) & anti-topoisomerase antibodies.[18]
DRB1*1503 is associated with Chaga's cardiomyopathy[19], allergic bronchopulmonary aspergillosis[12], multiple sclerosis[13], cervical cancer (human papillomavirus infection).[20]
[edit] Extended linkage
DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)[20]
DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus[17]
[edit] Genetic Linkage
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DR15 Haplotypes
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| Serotypes | DRA | DRB1 | DRB5 |
|---|---|---|---|
| DR15(2)-DR51 | *0101 | *1501 | *0101 |
| *0101 | *1502 | *0101 | |
| *0101 | *1503 | *0101 | |
| *0101 | *1504 | *0101 | |
| *0101 | *1505 | *0101 | |
| *0101 | *1507 | *0101 | |
| DQA1 | DQB1 | DRB1 | |
| DR15(2)-DQ6(6.2, 1) | *0102 | *0602 | *1501 |
| DR15(2)-DQ6(6.1, 1) | *0103 | *0601 | *1502 |
| HLA-A | HLA-B | DRB1 | |
| A3-Cw7-B7-DR15(2) | *0301 | *0702 | *1501 |
| A1-B51-DR15(2) | *0101 | *5101 | *1502 |
HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.
[edit] References
- ^ derived from IMGT/HLA
- ^ Phelps R, Jones V, Turner A, Rees A (2000). "Properties of HLA class II molecules divergently associated with Goodpasture's disease.". Int Immunol 12 (8): 1135–43. doi:10.1093/intimm/12.8.1135. PMID 10917888.
- ^ Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J (2000). "HLA-DR15 is associated with lower age at onset in multiple sclerosis.". Ann Neurol 48 (2): 211–9. doi:10.1002/1531-8249(200008)48:2<211::AID-ANA11>3.0.CO;2-R. PMID 10939572.
- ^ Ungar B, Mathews J, Tait B, Cowling D (1981). "HLA-DR patterns in pernicious anaemia". Br Med J (Clin Res Ed) 282 (6266): 768–70. doi:10.1136/bmj.282.6266.768. PMC 1504598. PMID 6783164. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1504598.
- ^ Bilir M, Sipahi S, Yilmaz E et al (2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356–9. doi:10.1097/SMJ.0b013e31802f3763. PMID 17458393.
- ^ Hong SC, Lin L, Lo B et al (January 2007). "DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans". Hum. Immunol. 68 (1): 59–68. doi:10.1016/j.humimm.2006.10.006. PMID 17207713.
- ^ Peled N, Amar A, Peled E, Brautbar C, Pillar G (2002). "DRB1*1502-DQB1*0601-DQA1*0103 and DRB1*04-DQB1*0302 in Jewish hypersomnolent patients". Sleep Med. 3 (3): 267–70. doi:10.1016/S1389-9457(01)00155-1. PMID 14592217.
- ^ Douroudis K, Tarassi K, Athanassiades T et al (2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens 69 (6): 592–6. doi:10.1111/j.1399-0039.2007.00833.x. PMID 17498269.
- ^ Robertson J, Wu J, Arends J, Glass W, Southwood S, Sette A, Lou Y (2005). "Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis". Kidney Int 68 (3): 1061–70. doi:10.1111/j.1523-1755.2005.00498.x. PMID 16105036.
- ^ Phelps R, Rees A (1999). "The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity". Kidney Int 56 (5): 1638–53. doi:10.1046/j.1523-1755.1999.00720.x. PMID 10571772.
- ^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
- ^ a b Slavin R, Hutcheson P, Chauhan B, Bellone C (2004). "An overview of allergic bronchopulmonary aspergillosis with some new insights". Allergy Asthma Proc 25 (6): 395–9. PMID 15709450.
- ^ a b Quelvennec E, Bera O, Cabre P, Alizadeh M, Smadja D, Judge F, Edan G, Semana G (2003). "Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome". Tissue Antigens 61 (2): 166–71. doi:10.1046/j.0001-2815.2002.00008.x. PMID 12694585.
- ^ Takeuchi F, Nakano K, Nabeta H, Hong G, Kawasugi K, Mori M, Okudaira H, Kuwata S, Tanimoto K (2005). "Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients". Int J Immunogenet 32 (3): 173–8. doi:10.1111/j.1744-313X.2005.00504.x. PMID 15932622.
- ^ Apple R, Erlich H, Klitz W, Manos M, Becker T, Wheeler C (1994). "HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity". Nat Genet 6 (2): 157–62. doi:10.1038/ng0294-157. PMID 8162070.
- ^ Manoussakis M, Georgopoulou C, Zintzaras E, Spyropoulou M, Stavropoulou A, Skopouli F, Moutsopoulos H (2004). "Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome". Arthritis Rheum 50 (3): 882–91. doi:10.1002/art.20093. PMID 15022331.
- ^ a b Sirikong M, Tsuchiya N, Chandanayingyong D, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K (2002). "Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais". Tissue Antigens 59 (2): 113–7. doi:10.1034/j.1399-0039.2002.590206.x. PMID 12028537.
- ^ Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum 42 (3): 465–74. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769.
- ^ García Borrás S, Diez C, Cotorruelo C, Pellizon O, Biondi C, Beloscar J, Bottasso O, Racca A (2006). "HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection". Ann Clin Biochem 43 (Pt 3): 214–6. doi:10.1258/000456306776865205. PMID 16704757.
- ^ a b Maciag P, Schlecht N, Souza P, Franco E, Villa L, Petzl-Erler M (2000). "Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women". Cancer Epidemiol Biomarkers Prev 9 (11): 1183–91. PMID 11097225.
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