HLA-DRB3 (gene)

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Major histocompatibility complex, class II, DR beta 3
2Q6W.png
Structure of HLA-DRB3 (green) complexed with HLA-DRA (cyan) and a fragment of Integrin, beta 3 (magenta) based on the PDB 2Q6W coordinates.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HLA-DRB3 ; HLA-DR3B
External IDs OMIM612735 HomoloGene123833 ChEMBL: 3460 GeneCards: HLA-DRB3 Gene
RNA expression pattern
PBB GE HLA-DRB3 209312 x at tn.png
PBB GE HLA-DRB3 215193 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3125 n/a
Ensembl ENSG00000196101 n/a
UniProt P79483 n/a
RefSeq (mRNA) NM_022555 n/a
RefSeq (protein) NP_072049 n/a
Location (UCSC) Chr HSCHR6_MHC_APD:
32.47 – 32.48 Mb
n/a
PubMed search [1] n/a

HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the HLA-DRB3 gene.[1]

Function[edit]

The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).[1]

Gene structure and polymorphisms[edit]

The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.[1]

Gene expression[edit]

DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.[1]

See also[edit]

References[edit]

Further reading[edit]