HLA-DRB5

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Major histocompatibility complex, class II, DR beta 5
1FV1.png
Structure of HLA-DRB5 (green) complexed with HLA-DRA (cyan) and a fragment of MBP (magenta) based on the PDB 1FV1 coordinates.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HLA-DRB5 ; HLA-DRB
External IDs OMIM604776 HomoloGene101524 GeneCards: HLA-DRB5 Gene
Orthologs
Species Human Mouse
Entrez 3127 14969
Ensembl ENSG00000198502 ENSMUSG00000060586
UniProt Q30154 n/a
RefSeq (mRNA) NM_002125 NM_010382
RefSeq (protein) NP_002116 NP_034512
Location (UCSC) Chr 6:
32.49 – 32.5 Mb
Chr 17:
34.31 – 34.32 Mb
PubMed search [1] [2]

HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene.[1]

Function[edit]

The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).[1]

Gene structure and polymorphisms[edit]

The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.[1]

Gene expression[edit]

DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.[1]

See also[edit]

References[edit]

Further reading[edit]