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Helicase-like transcription factor
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HLTF ; HIP116; HIP116A; HLTF1; RNF80; SMARCA3; SNF2L3; ZBU1
External IDs OMIM603257 MGI1196437 HomoloGene30136 GeneCards: HLTF Gene
RNA expression pattern
PBB GE HLTF 202983 at tn.png
More reference expression data
Species Human Mouse
Entrez 6596 20585
Ensembl ENSG00000071794 ENSMUSG00000002428
UniProt Q14527 Q6PCN7
RefSeq (mRNA) NM_003071 NM_009210
RefSeq (protein) NP_003062 NP_033236
Location (UCSC) Chr 3:
148.75 – 148.8 Mb
Chr 3:
20.06 – 20.12 Mb
PubMed search [1] [2]

Helicase-like transcription factor is an enzyme that in humans is encoded by the HLTF gene.[1][2]


This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.[2]

HLTF is a double-stranded DNA translocase, one of two human homologs of Saccharomyces cerevisiae RAD5 besides SHPRH (SNF2 histone linker PHD RING helicase), that is able to carry out fork regression, similarly to Rad5.[3]


HLTF has been shown to interact with UBE2N,[4] RAD18[4] and UBE2V2 [4](see also STRING functional and physical associations network : under the option 'search by name' enter 'protein name' of interest, HLTF, klick on 'GO! ', choose 'organism ', klick on 'continue ->' ).


  1. ^ Lin Y, Sheridan PL, Jones KA, Evans GA (Nov 1995). "The HIP116 SNF2/SW12-related transcription factor gene (SNF2L3) is located on human chromosome 3q25.1-q26.1". Genomics 27 (2): 381–2. doi:10.1006/geno.1995.1064. PMID 7558014. 
  2. ^ a b "Entrez Gene: HLTF helicase-like transcription factor". 
  3. ^ Unk I, Hajdú I, Blastyák A, Haracska L. (Jan 2010). "Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance". DNA Repair (Amst) 9 (3): 257–67. doi:10.1016/j.dnarep.2009.12.013. PMID 20096653. 
  4. ^ a b c Unk I, Hajdú I, Fátyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L (March 2008). "Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3768–73. doi:10.1073/pnas.0800563105. PMC 2268824. PMID 18316726. 

Further reading[edit]