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Histocompatibility (minor) 13
Symbols HM13 ; H13; IMP1; IMPAS; IMPAS-1; MSTP086; PSENL3; PSL3; SPP; SPPL1; dJ324O17.1
External IDs OMIM607106 MGI95886 HomoloGene7749 GeneCards: HM13 Gene
Species Human Mouse
Entrez 81502 14950
Ensembl ENSG00000101294 ENSMUSG00000019188
UniProt Q8TCT9 Q9D8V0
RefSeq (mRNA) NM_030789 NM_001159551
RefSeq (protein) NP_110416 NP_001153023
Location (UCSC) Chr 20:
30.1 – 30.16 Mb
Chr 2:
152.67 – 152.71 Mb
PubMed search [1] [2]

Minor histocompatibility antigen H13 is a protein that in humans is encoded by the HM13 gene.[1][2][3]


The minor histocompatibility antigen 13 is a nonamer peptide that originates from a protein encoded by the H13 gene.[3][4] The peptide is generated by the cytosol by the proteasome, enters the endoplasmic reticulum (ER) lumen by the transporter associated with antigen processing (TAP) and is presented on the cell surface on H2-Db major histocompatibility anigen I (MHC I) molecules. The alloreactivity, which leads to transplant rejection in mice, is conferred by Val/Ile polymorphism in the ‘SSV(V/I)GVWYL’ peptide.[5] The orthologue gene in humans is called HM13. If a related polymorphism exists, and if the HM13 serves as a Minor histocompatibility antigen, however, remains to be addressed.

The protein encoded by the M13/HM13 gene is the signal peptide peptidase (SPP), an ER-resident intramembrane protease.[1] SPP localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.[3]


  1. ^ a b Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B (Jun 2002). "Identification of signal peptide peptidase, a presenilin-type aspartic protease". Science 296 (5576): 2215–8. doi:10.1126/science.1070925. PMID 12077416. 
  2. ^ Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE (Apr 2004). "Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor". J Biol Chem 279 (15): 15153–60. doi:10.1074/jbc.M309305200. PMID 14704149. 
  3. ^ a b c "Entrez Gene: HM13 histocompatibility (minor) 13". 
  4. ^ Snell GD, Cudkowicz G, Bunker HP (Jun 1967). "Histocompatibility genes of mice. VII. H-13, a new histocompatibility locus in the fifth linkage group". Transplantation 5 (3): 492–503. doi:10.1097/00007890-196705000-00011. PMID 5340356. 
  5. ^ Mendoza LM, Paz P, Zuberi A, Christianson G, Roopenian D, Shastri N (Oct 1997). "Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex". Immunity 7 (4): 461–72. doi:10.1016/S1074-7613(00)80368-4. PMID 9354467. 

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