HMB-45
HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas, and stands for for Human Melanoma Black. It is used in anatomic pathology as a marker for such tumors.
HMB-45 was discovered by Drs. Allen M. Gown and Arthur M. Vogel in 1986.[1] The antibody was generated to an extract of melanoma. It reacts positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity. The antibody also reacts positively against junctional nevus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes.
HMB-45 is nonreactive with almost all non-melanoma human malignancies, with the exception of rare tumors showing evidence of melanogenesis (e.g., pigmented schwannoma, clear cell sarcoma) or tumors associated with tuberous sclerosis complex (angiomyolipoma and lymphangiomyoma).[2]
[edit] References
- ^ Gown AM, Vogel AM, Hoak D, Gough F, McNutt MA (1986). "Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes". Am. J. Pathol. 123 (2): 195–203. PMC 1888307. PMID 3518473. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1888307.
- ^ Mahmood, M. N.; Lee, M. W.; Linden, M. D.; Nathanson, S. D.; Hornyak, T. J.; Zarbo, R. J. (2002). "Diagnostic Value of HMB-45 and Anti-Melan a Staining of Sentinel Lymph Nodes with Isolated Positive Cells". Modern Pathology 15 (12): 1288–1293. doi:10.1097/01.MP.0000037313.33138.DF. PMID 12481009.
[edit] External links
- Melanoma Marker (HMB45) Antibody - www.scbt.com
- Melanoma antibody (ab787) datasheet - abcam.com.
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