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HMG coenzyme A.svg
CAS number 1553-55-5 YesY
PubChem 445127
ChemSpider 392859 YesY
ChEBI CHEBI:61659 YesY
Jmol-3D images Image 1
Molecular formula C27H44N7O20P3S
Molar mass 911.661 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

HMG-CoA (or 3-hydroxy-3-methylglutaryl-coenzyme A) is an intermediate in the mevalonate and ketogenesis pathways. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase.

It is also an intermediate in the metabolism of leucine. Its immediate precursor is 3-methylglutaconyl CoA.

Mevalonate pathway[edit]

Main article: Mevalonate pathway

HMG-CoA reductase converts it into mevalonic acid.

Mevalonate pathway

Ketogenesis pathway[edit]

HMG-CoA lyase breaks it into acetyl CoA and acetoacetate.