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High mobility group 20B
Protein HMG20B PDB 2crj.png
PDB rendering based on 2crj.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HMG20B ; BRAF25; BRAF35; HMGX2; HMGXB2; PP7706; SMARCE1r; SOXL; pp8857
External IDs OMIM605535 MGI1341190 HomoloGene74949 GeneCards: HMG20B Gene
RNA expression pattern
PBB GE HMG20B 210719 s at tn.png
PBB GE HMG20B 209113 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10362 15353
Ensembl ENSG00000064961 ENSMUSG00000020232
UniProt Q9P0W2 Q9Z104
RefSeq (mRNA) NM_006339 NM_001163165
RefSeq (protein) NP_006330 NP_001156637
Location (UCSC) Chr 19:
3.57 – 3.58 Mb
Chr 10:
81.35 – 81.35 Mb
PubMed search [1] [2]

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.[1][2]


HMG20B has been shown to interact with KIF4A,[3] HDAC1,[4] Histone deacetylase 2,[4][5] PHF21A,[4][6] RCOR1[4] and BRCA2.[4][7]


  1. ^ Sumoy L, Carim L, Escarceller M, Nadal M, Gratacos M, Pujana MA, Estivill X, Peral B (Jun 2000). "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression". Cytogenet Cell Genet 88 (1–2): 62–7. doi:10.1159/000015486. PMID 10773667. 
  2. ^ "Entrez Gene: HMG20B high-mobility group 20B". 
  3. ^ Lee, Young Mi; Kim Wankee (Sep 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". Biochem. J. (England) 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554. 
  4. ^ a b c d e Hakimi, Mohamed-Ali; Bochar Daniel A; Chenoweth Josh; Lane William S; Mandel Gail; Shiekhattar Ramin (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (11): 7420–5. doi:10.1073/pnas.112008599. ISSN 0027-8424. PMC 124246. PMID 12032298. 
  5. ^ Hakimi, Mohamed-Ali; Dong Yuanshu; Lane William S; Speicher David W; Shiekhattar Ramin (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. (United States) 278 (9): 7234–9. doi:10.1074/jbc.M208992200. ISSN 0021-9258. PMID 12493763. 
  6. ^ Iwase, Shigeki; Januma Aya; Miyamoto Kiyoko; Shono Naomi; Honda Arata; Yanagisawa Junn; Baba Tadashi (Sep 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. (United States) 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. ISSN 0006-291X. PMID 15325272. 
  7. ^ Marmorstein, L Y; Kinev A V; Chan G K; Bochar D A; Beniya H; Epstein J A; Yen T J; Shiekhattar R (Jan 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell (United States) 104 (2): 247–57. doi:10.1016/S0092-8674(01)00209-4. ISSN 0092-8674. PMID 11207365. 

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