HMGA is a family of high mobility group proteins characterized by an AT-hook. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture". A recent study has shown variations in HMGA2 to have a moderate association with adult height. [1 ] [2 ] [3 ]
See also [ edit ]
References [ edit ]
^ Mayr C, Hemann MT, Bartel DP (2007). "Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation". Science 315 (5818): 1576–1579. doi: 10.1126/science.1137999. PMC 2556962. PMID 17322030.
^ "Scientists discover height gene". BBC News. 2007-09-03 . Retrieved 2007-09-03.
^ Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM (2007). "A common variant of HMGA2 is associated with adult and childhood height in the general population". Nat. Genet. 39 (10): 1245–1250. doi: 10.1038/ng2121. PMC 3086278. PMID 17767157.
External links [ edit ]
β-Scaffold factors with minor groove contacts
(0) Other transcription factors
transcription factor/coregulator deficiencies B bsyn: dna ( repl, cycl, reco, repr) · tscr ( fact, tcrg, nucl, rnat, rept, ptts) · tltn ( risu, pttl, nexn) · dnab, rnab/ runp · stru ( domn, 1°, 2°, 3°, 4°)