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Heme oxygenase (decycling) 2
Protein HMOX2 PDB 2q32.png
PDB rendering based on 2q32.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HMOX2 ; HO-2
External IDs OMIM141251 MGI109373 HomoloGene1611 IUPHAR: 1442 ChEMBL: 2546 GeneCards: HMOX2 Gene
EC number
RNA expression pattern
PBB GE HMOX2 218120 s at tn.png
PBB GE HMOX2 218121 at tn.png
More reference expression data
Species Human Mouse
Entrez 3163 15369
Ensembl ENSG00000103415 ENSMUSG00000004070
UniProt P30519 O70252
RefSeq (mRNA) NM_001127204 NM_001136066
RefSeq (protein) NP_001120676 NP_001129538
Location (UCSC) Chr 16:
4.52 – 4.56 Mb
Chr 16:
4.73 – 4.77 Mb
PubMed search [1] [2]

Heme oxygenase 2 is an enzyme that in humans is encoded by the HMOX2 gene.[1][2]


Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 (this enzyme) belong to the heme oxygenase family.[2]


  1. ^ McCoubrey WK, Ewing JF, Maines MD (Jun 1992). "Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal". Arch Biochem Biophys 295 (1): 13–20. doi:10.1016/0003-9861(92)90481-B. PMID 1575508. 
  2. ^ a b "Entrez Gene: HMOX2 heme oxygenase (decycling) 2". 

Further reading[edit]