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Heterogeneous nuclear ribonucleoprotein C (C1/C2)

PDB rendering based on 1wf2.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM164020 MGI107795 HomoloGene74524 GeneCards: HNRNPC Gene
Species Human Mouse
Entrez 3183 15381
Ensembl ENSG00000092199 ENSMUSG00000060373
UniProt P07910 Q9Z204
RefSeq (mRNA) NM_001077442 NM_001170981
RefSeq (protein) NP_001070910 NP_001164452
Location (UCSC) Chr 14:
21.68 – 21.74 Mb
Chr 14:
52.07 – 52.1 Mb
PubMed search [1] [2]

Heterogeneous nuclear ribonucleoproteins C1/C2 is a protein that in humans is encoded by the HNRNPC gene.[1][2]

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.[3]


This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing(reference: Koenig J. nature structural and Molecular Biology 2010: iCLIP) and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.[2]


HNRNPC has been shown to interact with Grb2.[4]


  1. ^ Nakagawa TY, Swanson MS, Wold BJ, Dreyfuss G (May 1986). "Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family". Proc Natl Acad Sci U S A 83 (7): 2007–11. doi:10.1073/pnas.83.7.2007. PMC 323219. PMID 3457372. 
  2. ^ a b "Entrez Gene: HNRPC heterogeneous nuclear ribonucleoprotein C (C1/C2)". 
  3. ^ Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human placenta derived from assisted reproductive technology". Proteomics 8 (20): 4344–56. doi:10.1002/pmic.200800294. PMID 18792929. 
  4. ^ Romero, F; Ramos-Morales F, Domínguez A, Rios R M, Schweighoffer F, Tocqué B, Pintor-Toro J A, Fischer S, Tortolero M (Mar 1998). "Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA". J. Biol. Chem. (UNITED STATES) 273 (13): 7776–81. doi:10.1074/jbc.273.13.7776. ISSN 0021-9258. PMID 9516488. 

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