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Heterogeneous nuclear ribonucleoprotein L
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603083 MGI104816 HomoloGene1174 GeneCards: HNRNPL Gene
RNA expression pattern
PBB GE HNRPL 35201 at tn.png
PBB GE HNRPL 202072 at tn.png
More reference expression data
Species Human Mouse
Entrez 3191 15388
Ensembl ENSG00000104824 ENSMUSG00000015165
UniProt P14866 Q8R081
RefSeq (mRNA) NM_001005335 NM_177301
RefSeq (protein) NP_001005335 NP_796275
Location (UCSC) Chr 19:
39.33 – 39.34 Mb
Chr 7:
28.81 – 28.82 Mb
PubMed search [1] [2]

Heterogeneous nuclear ribonucleoprotein L is a protein that in humans is encoded by the HNRNPL gene.[1][2]


Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.[2]


HNRNPL has been shown to interact with:


  1. ^ Pinol-Roma S, Swanson MS, Gall JG, Dreyfuss G (January 1990). "A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts". J Cell Biol 109 (6 Pt 1): 2575–87. doi:10.1083/jcb.109.6.2575. PMC 2115934. PMID 2687284. 
  2. ^ a b "Entrez Gene: HNRPL heterogeneous nuclear ribonucleoprotein L". 
  3. ^ Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A (Aug 2008). "Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL". Science 321 (5889): 686–91. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861. 
  4. ^ a b c Kim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol. 298 (3): 395–405. doi:10.1006/jmbi.2000.3687. PMID 10772858. 
  5. ^ Hahm B, Cho OH, Kim JE, Kim YK, Kim JH, Oh YL, Jang SK (April 1998). "Polypyrimidine tract-binding protein interacts with HnRNP L". FEBS Lett. 425 (3): 401–6. doi:10.1016/S0014-5793(98)00269-5. PMID 9563502. 

Further reading[edit]