Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
^ abcKim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol.298 (3): 395–405. doi:10.1006/jmbi.2000.3687. PMID10772858.
Rasmussen HH, van Damme J, Puype M et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis13 (12): 960–9. doi:10.1002/elps.11501301199. PMID1286667.CS1 maint: Explicit use of et al. (link)
Shih SC, Claffey KP (1999). "Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L". J. Biol. Chem.274 (3): 1359–65. doi:10.1074/jbc.274.3.1359. PMID9880507.
Hamilton BJ, Nichols RC, Tsukamoto H et al. (1999). "hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo". Biochem. Biophys. Res. Commun.261 (3): 646–51. doi:10.1006/bbrc.1999.1040. PMID10441480.CS1 maint: Explicit use of et al. (link)
Kim JH, Hahm B, Kim YK et al. (2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol.298 (3): 395–405. doi:10.1006/jmbi.2000.3687. PMID10772858.CS1 maint: Explicit use of et al. (link)
Shnyreva M, Schullery DS, Suzuki H et al. (2000). "Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein". J. Biol. Chem.275 (20): 15498–503. doi:10.1074/jbc.275.20.15498. PMID10809782.CS1 maint: Explicit use of et al. (link)
Ito M, Shichijo S, Tsuda N et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells". Cancer Res.61 (5): 2038–46. PMID11280764.CS1 maint: Explicit use of et al. (link)
Söderberg M, Raffalli-Mathieu F, Lang MA (2002). "Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA". Mol. Pharmacol.62 (2): 423–31. doi:10.1124/mol.62.2.423. PMID12130696.
Hui J, Stangl K, Lane WS, Bindereif A (2007). "HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats". Nat. Struct. Biol.10 (1): 33–7. doi:10.1038/nsb875. PMID12447348.
Gulesserian T, Engidawork E, Fountoulakis M, Lubec G (2004). "Decreased brain levels of Lupus La protein and increased U5 small ribonucleoprotein-specific 40 kDa protein in fetal Down syndrome". Cell. Mol. Biol. (Noisy-le-grand)49 (5): 733–8. PMID14528909.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.CS1 maint: Explicit use of et al. (link)
Cheng J, Kapranov P, Drenkow J et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science308 (5725): 1149–54. doi:10.1126/science.1108625. PMID15790807.CS1 maint: Explicit use of et al. (link)