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Heterogeneous nuclear ribonucleoprotein A2/B1
Protein HNRPA2B1 PDB 1x4b.png
PDB rendering based on 1x4b.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600124 MGI104819 HomoloGene22992 GeneCards: HNRNPA2B1 Gene
RNA expression pattern
PBB GE HNRPA2B1 205292 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3181 53379
Ensembl ENSG00000122566 ENSMUSG00000004980
UniProt P22626 O88569
RefSeq (mRNA) NM_002137 NM_016806
RefSeq (protein) NP_002128 NP_058086
Location (UCSC) Chr 7:
26.23 – 26.24 Mb
Chr 6:
51.46 – 51.47 Mb
PubMed search [1] [2]

Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans is encoded by the HNRNPA2B1 gene.[1]


This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.[2] HnRNPA2B1 is an autoantigen in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and mixed connective tissue disease. When referred to as an autoantigen, hnRNPA2B1 is also known as RA33.


HNRPA2B1 has been shown to interact with Casein kinase 2, alpha 1.[3]


  1. ^ Biamonti G, Ruggiu M, Saccone S, Della Valle G, Riva S (Aug 1994). "Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1". Nucleic Acids Res. 22 (11): 1996–2002. doi:10.1093/nar/22.11.1996. PMC 308112. PMID 8029005. 
  2. ^ "Entrez Gene: HNRPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1". 
  3. ^ Pancetti F, Bosser R, Krehan A, Pyerin W, Itarte E, Bachs O (Jun 1999). "Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2". Biochem. Biophys. Res. Commun. 260 (1): 17–22. doi:10.1006/bbrc.1999.0849. PMID 10381337. 

Further reading[edit]