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Heterogeneous nuclear ribonucleoprotein H1 (H)
Protein HNRPH1 PDB 1wez.png
PDB rendering based on 1wez.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM601035 MGI1891925 HomoloGene31318 GeneCards: HNRNPH1 Gene
RNA expression pattern
PBB GE HNRPH1 201031 s at tn.png
PBB GE HNRPH1 213470 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3187 59013
Ensembl ENSG00000169045 ENSMUSG00000007850
UniProt P31943 O35737
RefSeq (mRNA) NM_001257293 NM_021510
RefSeq (protein) NP_001244222 NP_067485
Location (UCSC) Chr 5:
179.04 – 179.06 Mb
Chr 11:
50.38 – 50.39 Mb
PubMed search [1] [2]

Heterogeneous nuclear ribonucleoprotein H is a protein that in humans is encoded by the HNRNPH1 gene.[1][2]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. It is very similar to the family member HNRPF. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype.[2]


  1. ^ Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem 270 (48): 28780–9. doi:10.1074/jbc.270.48.28780. PMID 7499401. 
  2. ^ a b "Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)". 

Further reading[edit]