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Heterogeneous nuclear ribonucleoprotein K
Protein HNRPK PDB 1j5k.png
PDB rendering based on 1j5k.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600712 MGI99894 HomoloGene81909 ChEMBL: 3469 GeneCards: HNRNPK Gene
RNA expression pattern
PBB GE HNRPK 200775 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3190 15387
Ensembl ENSG00000165119 ENSMUSG00000021546
UniProt P61978 P61979
RefSeq (mRNA) NM_002140 NM_025279
RefSeq (protein) NP_002131 NP_079555
Location (UCSC) Chr 9:
86.58 – 86.6 Mb
Chr 13:
58.39 – 58.4 Mb
PubMed search [1] [2]

Heterogeneous nuclear ribonucleoprotein K is a protein that in humans is encoded by the HNRNPK gene.[1]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Multiple alternatively spliced transcript variants have been described for this gene but only three variants have been fully described.[2]


HNRPK has been shown to interact with KHDRBS1,[3] PCBP2,[4] PTBP1,[4] DDX1,[5] PRMT1,[6][7] HNRNPL[4] and C-src tyrosine kinase.[8]


  1. ^ Dejgaard K, Leffers H, Rasmussen HH, Madsen P, Kruse TA, Gesser B, Nielsen H, Celis JE (March 1994). "Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing". J Mol Biol 236 (1): 33–48. doi:10.1006/jmbi.1994.1116. PMID 8107114. 
  2. ^ "Entrez Gene: HNRPK heterogeneous nuclear ribonucleoprotein K". 
  3. ^ Yang, Jian-Ping; Reddy Thipparthi R, Truong Ky T, Suhasini Modem, Wong-Staal Flossie (October 2002). "Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K". Oncogene (England) 21 (47): 7187–94. doi:10.1038/sj.onc.1205759. ISSN 0950-9232. PMID 12370808. 
  4. ^ a b c Kim, J H; Hahm B; Kim Y K; Choi M; Jang S K (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol. (ENGLAND) 298 (3): 395–405. doi:10.1006/jmbi.2000.3687. ISSN 0022-2836. PMID 10772858. 
  5. ^ Chen, Hui-Chin; Lin Wei-Chin; Tsay Yeou-Guang; Lee Sheng-Chung; Chang Ching-Jin (October 2002). "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K". J. Biol. Chem. (United States) 277 (43): 40403–9. doi:10.1074/jbc.M206981200. ISSN 0021-9258. PMID 12183465. 
  6. ^ Côté, Jocelyn; Boisvert Francois-Michel; Boulanger Marie-Chloé; Bedford Mark T; Richard Stéphane (January 2003). "Sam68 RNA Binding Protein Is an In Vivo Substrate for Protein Arginine N-Methyltransferase 1". Mol. Biol. Cell (United States) 14 (1): 274–87. doi:10.1091/mbc.E02-08-0484. ISSN 1059-1524. PMC 140244. PMID 12529443. 
  7. ^ Wada, Kazuhiro; Inoue Koichi; Hagiwara Masatoshi (August 2002). "Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy". Biochim. Biophys. Acta (Netherlands) 1591 (1–3): 1–10. doi:10.1016/S0167-4889(02)00202-1. ISSN 0006-3002. PMID 12183049. 
  8. ^ Ostareck-Lederer, Antje; Ostareck Dirk H, Cans Christophe, Neubauer Gitte, Bomsztyk Karol, Superti-Furga Giulio, Hentze Matthias W (July 2002). "c-Src-Mediated Phosphorylation of hnRNP K Drives Translational Activation of Specifically Silenced mRNAs". Mol. Cell. Biol. (United States) 22 (13): 4535–43. doi:10.1128/MCB.22.13.4535-4543.2002. ISSN 0270-7306. PMC 133888. PMID 12052863. 

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