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Homer homolog 3 (Drosophila)
Protein HOMER3 PDB 2P8V.png
Rendering based on PDB 2P8V.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HOMER3 ; HOMER-3; VESL3
External IDs OMIM604800 MGI1347359 HomoloGene37972 GeneCards: HOMER3 Gene
RNA expression pattern
PBB GE HOMER3 204647 at tn.png
PBB GE HOMER3 215489 x at tn.png
PBB GE HOMER3 222222 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9454 26558
Ensembl ENSG00000051128 ENSMUSG00000003573
UniProt Q9NSC5 Q99JP6
RefSeq (mRNA) NM_001145721 NM_001146153
RefSeq (protein) NP_001139193 NP_001139625
Location (UCSC) Chr 19:
19.04 – 19.05 Mb
Chr 8:
70.28 – 70.29 Mb
PubMed search [1] [2]

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.[1][2][3]

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.[3]


HOMER3 has been shown to interact with TRPC1[4] and RYR1.[5]

See also[edit]


  1. ^ Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (Apr 2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". J Mol Biol 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696. 
  2. ^ Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Dec 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. 
  3. ^ a b "Entrez Gene: HOMER3 homer homolog 3 (Drosophila)". 
  4. ^ Yuan, Joseph P; Kiselyov Kirill, Shin Dong Ming, Chen Jin, Shcheynikov Nikolay, Kang Shin H, Dehoff Marlin H, Schwarz Martin K, Seeburg Peter H, Muallem Shmuel, Worley Paul F (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell (United States) 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. ISSN 0092-8674. PMID 14505576. 
  5. ^ Feng, Wei; Tu Jiancheng; Yang Tianzhong; Vernon Patty Shih; Allen Paul D; Worley Paul F; Pessah Isaac N (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. (United States) 277 (47): 44722–30. doi:10.1074/jbc.M207675200. ISSN 0021-9258. PMID 12223488. 

Further reading[edit]